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OJBTM
Online Journal of Bioinformatics ©
Volume 12(2):207-216, 2011
Comparative
modeling studies of a hypothetical protein YHR105W from S.Cerevisae genome.
1N Rathankar, 2HG Nagendra*
1 Asst. Professor, School of Bioengineering, Department of Bioinformatics,
SRM University, Kattankulathur campus, hennai and 2 Prof. and HOD, Dept. of
Biotechnology, Sir M. Visvesvaraya Institute of Technology,
Krishnadevarayanagar, unasamaranahalli,
Bangalore, India.
ABSTRACT
Rathankar
N, Nagendra HG., Comparative modeling studies of a hypothetical protein YHR105W
from S. Cerevisiae genome, Onl J Bioinform,
12(2):207-216, 2011.The first Eukaryotic genome to be
sequenced in 1966 was the common Baker’s Yeast, S.Cerevisae. It is used as a
model organism, as it shares similarity with a vast number of genes, proteins and genetic pathways
in humans. A suitable sequence was selected for comparative modeling studies.
Results revealed that, though the sequence similarity with the targets from PDB
were lower than 25%, the structural homology between the template and the model
hypothetical protein YHR105W was found to be high, suggesting similar
functional roles.
Key Words: Modeled protein,
S Cerevisae genome.