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Online Journal of Bioinformatics ©
Volume 18(1):39-46, 2017.
Model docking of human 2,3 dioxygenase to Adhatoda vasica, Biophytum sensitivum
and Caesalpinia bonduc extracts for prevention of cataract.
Vrukonda Nagalaxmi, Turlapati NagaRaju.
Department of Zoology, Physiology Division and University College of Science, Osmania University, Hyderabad-07, India.
Nagalaxmi V, NagaRaju T., Model docking of human indoleamine 2,3 dioxygenase to Adhatoda vasica, Biophytum sensitivum and Caesalpinia bonduc for prevention of cataract. Onl J Bioinform., 18(1):39-46, 2017. Gas chromatography and mass spectrometry was used to identify compounds present in ethanolic extracts of Adhatoda vasica, Biophytum sensitivum and Caesalpinia bonduc, docked In silico to indoleamine 2,3 dioxygenase which has a role in causing cataract. Results suggested that of 15 compounds tested, Androstane 3,17-dione had greatest binding affinity with Indoleamine 2, 3 dioxygenase.
Key words: Cataracts, Model, Docking, Indoleamine 2, 3 dioxygenase.