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Online Journal of Bioinformatics ©
Volume 18(1):1-6, 2017
In-Silico human, cow and sheep milk alpha casein S1, fibronectin, lactoferrin and lysozyme as predictors of hypersensitivity and malnutrition in infants.
Jitesh Pandey, Shivani Sharma MSc
Wrignano Systems Pvt. Ltd., Delhi; Batch of 2015, Department of Life Sciences, Institute of Applied Medicine and Research, Duhai, Ghaziabad, Ottar Pradesh, India
Pandey J, Sharma S., In-Silico human, cow and sheep milk alpha casein S1, fibronectin, lactoferrin and lysozyme for prediction of hypersensitivity and malnutrition in infants, Onl J Bioinform., 18(1):1-6, 2017. In developing Asia, ~2.6% infants cannot digest cow milk inducing cow milk allergy (CMA). In silico human, cow and sheep alpha casein S1 protein, fibronectin, lactoferrin and lysozyme present in milk were used as In Silico predictors for milk hypersensitivity and malnutrition in infants. To identify protein structure, multiple sequence alignment by CLUSTALW2 was performed to determine constraints imposed by structure and function on evolution of whole protein milk families. Protein constituents were visualized with PROTPARAM and prediction of secondary structure with GOR. We find that human and sheep proteins share greater similarity by sequence identity and amino acid content compared with cow milk. Cow milk had a higher percentage of essential amino acids compared with other milk which may explain why different milks could induce hyper-allergies. Our results support the contention that sheep milk could be used to replace human milk in case of allergy in infants but cow milk in case of malnutrition due to high lysine content.
KEYWORDS: Milk Protein, Casein Alpha S1, Lactoferrin, Fibronectin and Lysozyme, Secondary Structure Prediction, Comparative Genomics. Raw data and programs provided.
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