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OJBTM
Online Journal of
Bioinformatics©
Established 1995
ISSN 1443-2250
Volume 24 (1):1-5, 2023.
Functional
genomics of Carboxydothermus hydrogenoformans CO-metabolism and hydrogen
production
Chinnasamy
Perumal Rajadurai and Gopal
Ramesh Kumar *
Bioinformatics Lab,
AU-KBC Research Centre, MIT Campus, Anna University Chennai, Chromepet, Chennai 600 044.India,
Rajadurai CP, Kumar GR., Functional genomics of Carboxydothermus hydrogenoformans
CO metabolism and hydrogen production, Onl J Bioinform., 24 (1):1-5, 2023. We
report manual re-annotation of whole genome of Carboxydothermus hydrogenoformans
Z-2901 to identify functions of putative coding regions. Carboxydotroph
C. hydrogenoformans
produces hydrogen by using carbon monoxide for energy. Functions of ~1,536
protein sequences have been assigned in C. hydrogenoformans genome but others are unassigned. We
complete re-annotation by homology search, pattern or motif prediction and fold
recognition to identify and assign the functions of unknown proteins that could
code for CO dehydrogenase (CODH), involved in hydrogen production. There are 855 unknown coding sequences (CDS)
manually re-analyzed and annotated. Functions of 633 coding sequences have been
predicted, of which 21 share functional identity with array of genes specific
to carbon metabolism. Only 4 are considered putative CODH enzymes thast could enhance hydrogen production.
Keywords: re-annotation, Carboxydothermus hydrogenoformans,
coding sequences, hydrogen molecule, hypothetical, putative, motif pattern.
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