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Online Journal of Bioinformatics

Established 1995

ISSN  1443-2250


Volume 24 (1):1-5, 2023.

Functional genomics of Carboxydothermus hydrogenoformans CO-metabolism and hydrogen production


Chinnasamy Perumal Rajadurai and Gopal Ramesh Kumar *


Bioinformatics Lab, AU-KBC Research Centre, MIT Campus, Anna University Chennai, Chromepet, Chennai 600 044.India,




Rajadurai CP, Kumar GR., Functional genomics of Carboxydothermus hydrogenoformans CO metabolism and hydrogen production, Onl J Bioinform., 24 (1):1-5, 2023. We report manual re-annotation of whole genome of Carboxydothermus hydrogenoformans Z-2901 to identify functions of putative coding regions. Carboxydotroph C. hydrogenoformans produces hydrogen by using carbon monoxide for energy. Functions of ~1,536 protein sequences have been assigned in C. hydrogenoformans genome but others are unassigned. We complete re-annotation by homology search, pattern or motif prediction and fold recognition to identify and assign the functions of unknown proteins that could code for CO dehydrogenase (CODH), involved in hydrogen production. There are 855 unknown coding sequences (CDS) manually re-analyzed and annotated. Functions of 633 coding sequences have been predicted, of which 21 share functional identity with array of genes specific to carbon metabolism. Only 4 are considered putative CODH enzymes thast could enhance hydrogen production.


Keywords: re-annotation, Carboxydothermus hydrogenoformans, coding sequences, hydrogen molecule, hypothetical, putative, motif pattern.