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OJB©

Online Journal of Bioinformatics©

Onl J Bioinform©


Established 1995

ISSN  1443-2250

 

Volume 25 (2) : 79-86, 2024.

Sequence phylogenetics of glucose-6-phosphate dehydrogenase in Bubalus bubalis

 

Kumar Ra1, Kaura Ra1, Kaura Sa1, Sethi Pb2, Srikala Ra1  

 

1Department(s) Animal Breeding and Genetics, College of Veterinary Medicine, Ludhiana, India, 2Poultry Science, University of Georgia,  Athens,USA

 

ABSTRACT 

 

Kumar R, Kaura R, Kaura S, Sethi P, Srikala R., Sequence phylogenetics of glucose-6-phosphate dehydrogenase in Bubalus bubalis., Onl J Bioinform., 25 (2) : 79-86, 2024.  Glucose-6-phosphate dehydrogenase (G6PD) has a crucial role in fatty acid biosynthesis and detoxification of organic peroxides governs synthesis of nucleotides by production of ribose-5-phosphate through hexose monophosphate pathway. We amplified a 683 bp fragment of buffalo G6PD gene and sequenced and characterized the clustered amino acid sequence G6PD of Bubalus bubalis into a monophyletic group. The multiple sequence alignment of Bubalus bubalis G6PD with the mammalian species clearly revealed conservation of the substrate and dimer binding sites with the solved X-ray crystallographic model structure of Homo sapiens.

 

Keywords - Glucose-6-phosphate-dehydrogenase, Buffalo, G6PD, Bubalus bubalis.

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