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Online Journal of Bioinformatics©
Volume 20(2):62-75, 2019.
BTDB - Database on Structural and Functional Information of Biotoxins.
Gowriishankar R and Sundara Baalaji N*
Structural Biology lab, Department of Bioinformatics, School of life sciences, Bharathiar University, Coimbatore – 641 046
Gowriishankar R, Baalaji SN., BTDB - Database on Structural and Functional Information of Biotoxins, Onl J Bioinform., 20(2):62-75, 2019. A biotoxic protein database could enable identification of membrane proteins, ion channels on the surface of cancer cells. We describe primary sequence databases for biotoxins from snake, spider and scorpion. We intended to study the 3D structures of the toxin proteins by homology modeling and validation of the structures through computational methods that will ease wet lab works. Structural features of the models and the putative functions are also predicted. For the easy access of the theoretically modeled proteins and other related data, database named BTDB was created which is user friendly and the information collected from this database will have the implications on further insilico analysis on cancer studies, designing drugs, studies on membrane proteins and identification of ion channels.
This database can be accessed at the URL: http://b-u.ac.in/btdb/
Keywords: Biotoxin, Polypeptide, Homology modeling, RMSD, Minimized energy, Database, HTML, MySQL