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 Online Journal of Bioinformatics  


Volume 8 (1) : 17-30, 2007.

Plasma Proteome Knowledgebase:Exploring Disease Biomarker Correlations


Iyer J, Srinivas VM, Khamari L, Sequeira JM, Das N, Periasamy UR, Bhate J



1 Molecular Connections Pvt. Ltd, Kandala Mansions, #2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore 560004, India




Iyer J, Srinivas VM, Khamari L, Sequeira JM, Das N, Periasamy UR, Bhate J., Plasma Proteome Knowledgebase:  Exploring Disease Biomarker Correlations, Onl J Bioinform 8(1) : 17-30, 2007. Blood represents one of the most complex and dynamic mammalian proteomes. Quantitative analysis of plasma proteome for disease diagnosis has significant clinical relevance as it could reflect the pathophysiological state of the organism. Thus, a curated database of plasma proteins could aid in analyzing and interpreting the vast pool of available data.  The plasma protein database that has been developed in-house contains concentration values mined from literature that reflect alterations between normal versus disease conditions. In addition, there are significant differences in the levels of plasma proteins, influenced by genetics, sex, age, gender, physiological state etc. Analysis of potentially important plasma protein concentrations compiled in the database has allowed us to identify and validate potential biomarker-disease associations. A comprehensive, easy to access plasma protein database with defined concentration values has been created, and the process involved in its development is described. The plasma catalog provides a concise snapshot of more than 500 clinically significant proteins, the concentration range reflecting the pathophysiological state of the organism


Key Words: database, plasma, proteome, diagnosis, biomarker, concentration, disease