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OJBTM
Online Journal of
Bioinformatics
©
Evolutionary
map of lateral gene transfer in biofilm-forming human pathogenic microorganisms
Nidhi Mathur,
Ravneet Chug.
Amity Institute of Biotechnology, Amity University,
Rajasthan.
ABSTRACT
Mathur N, Chug R., Evolutionary lineage of lateral gene transfer
in biofilm-forming human pathogenic microorganisms, Onl
J Bioinform., 14 (2):
160-167, 2013. Biofilms secreted by microbes in human infections create densely
packed communities of cells that grow on living or inert surfaces. The microbes
survive as a common entity to adapt to the environment and express specific
genes. 16s rRNA
gene sequences from 17 biofilm forming bacteria pathogenic to humans were extracted
from GenBank. Phylogenetic analysis revealed that the
microbes belonged to Legionella,
Staphylococcus and Alteromonas groups. Legionella pneumophila
was the oldest closely related to
a common ancestor. Protein auto-induction in 12 and 15 hemolytic toxin
of 17 bacteria evolved earliest in Salmonella
sp. Mycobacterium
tuberculosis was the most evolved
microbe. Lateral
Gene Transfer was evident in many groups due to a patchy, scattered
phylogenetic tree.
Key-words: Biofilms,
pathogenesis, phylogenetic analysis, toxicogenesis,16s
rRNA.
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