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Online Journal of Bioinformatics ©
Volume 14 (2): 160-167, 2013
Evolutionary map of lateral gene transfer in biofilm-forming human pathogenic microorganisms
Nidhi Mathur, Ravneet Chug.
Amity Institute of Biotechnology, Amity University, Rajasthan.
Mathur N, Chug R., Evolutionary lineage of lateral gene transfer in biofilm-forming human pathogenic microorganisms, Onl J Bioinform., 14 (2): 160-167, 2013. Biofilms secreted by microbes in human infections create densely packed communities of cells that grow on living or inert surfaces. The microbes survive as a common entity to adapt to the environment and express specific genes. 16s rRNA gene sequences from 17 biofilm forming bacteria pathogenic to humans were extracted from GenBank. Phylogenetic analysis revealed that the microbes belonged to Legionella, Staphylococcus and Alteromonas groups. Legionella pneumophila was the oldest closely related to a common ancestor. Protein auto-induction in 12 and 15 hemolytic toxin of 17 bacteria evolved earliest in Salmonella sp. Mycobacterium tuberculosis was the most evolved microbe. Lateral Gene Transfer was evident in many groups due to a patchy, scattered phylogenetic tree.
Key-words: Biofilms, pathogenesis, phylogenetic analysis, toxicogenesis,16s rRNA.