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OJBTM
Online Journal of Bioinformatics©
Volume 18(3):108-118, 2017.
In silico T-Cell
Bacillus
anthracis epitope
protective antigen - lethal factors
Anuraj Nayarisseri S*1,
Sheaza Ahmed S1, Mukesh
Yadav D1, Jyoti Sahu2, Priyanka
Gupta3, Rachna Chourasia2, Deepti Mittal R4
In
silico Research Laboratory, Eminent Biosciences, Vijaynagar,
Indore – Dept of Biotechnology, Softvision
College, Vijayanagar, Indore – Kalinga School of
Biotechnology, Patia, Bhubaneswar, Odisha, Dept. of
Bioinformatics, Dr. D. Y. Patil Biotechnology &
Bioinformatics Institute,Tathawade, Pune, India.
ABSTRACT:
Anuraj Nayarisseri
S, Sheaza Ahmed S, Mukesh
Yadav D, Jyoti Sahu,
Priyanka Gupta, Rachna Chourasia,
Deepti Mittal R., In silico T-Cell Bacillus anthracis
epitope protective antigen - lethal factors, Onl J Bioinform, 18(3):108-118, 2017.
A
major factor in the virulence of Bacillus anthracis is secretion of protective antigen,
lethal and edema toxins. These toxins possess a common cell receptor-binding (B)
component but have distinct biochemically active (A) components. We identified In silico T-Cell epitope and its binding
affinity with MHC Class II with HLAPred. Ideal
epitope peptide antigen, lipophilicity and solvency were determined. We
identified 10 protective antigen and 5 lethal factors with best epitopic characteristics. Further studies to predict
population coverage of T-cell epitope based on MHC binding data for
epitope-based vaccines or diagnostics are required.
Keywords: T-Cell Epitope, Bacillus
anthracis, Protective Antigen and Lethal factor.
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