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Online Journal of Bioinformatics©
Volume 18(3):108-118, 2017.
In silico T-Cell Bacillus anthracis epitope protective antigen - lethal factors
Anuraj Nayarisseri S*1, Sheaza Ahmed S1, Mukesh Yadav D1, Jyoti Sahu2, Priyanka Gupta3, Rachna Chourasia2, Deepti Mittal R4
In silico Research Laboratory, Eminent Biosciences, Vijaynagar, Indore – Dept of Biotechnology, Softvision College, Vijayanagar, Indore – Kalinga School of Biotechnology, Patia, Bhubaneswar, Odisha, Dept. of Bioinformatics, Dr. D. Y. Patil Biotechnology & Bioinformatics Institute,Tathawade, Pune, India.
Anuraj Nayarisseri S, Sheaza Ahmed S, Mukesh Yadav D, Jyoti Sahu, Priyanka Gupta, Rachna Chourasia, Deepti Mittal R., In silico T-Cell Bacillus anthracis epitope protective antigen - lethal factors, Onl J Bioinform, 18(3):108-118, 2017. A major factor in the virulence of Bacillus anthracis is secretion of protective antigen, lethal and edema toxins. These toxins possess a common cell receptor-binding (B) component but have distinct biochemically active (A) components. We identified In silico T-Cell epitope and its binding affinity with MHC Class II with HLAPred. Ideal epitope peptide antigen, lipophilicity and solvency were determined. We identified 10 protective antigen and 5 lethal factors with best epitopic characteristics. Further studies to predict population coverage of T-cell epitope based on MHC binding data for epitope-based vaccines or diagnostics are required.
Keywords: T-Cell Epitope, Bacillus anthracis, Protective Antigen and Lethal factor.