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OJBTM

Online Journal of Bioinformatics

Volume 18(3):108-118, 2017.


In silico T-Cell Bacillus anthracis epitope protective antigen - lethal factors

 

Anuraj Nayarisseri S*1, Sheaza Ahmed S1, Mukesh Yadav D1, Jyoti Sahu2, Priyanka Gupta3, Rachna Chourasia2, Deepti Mittal R4

 

In silico Research Laboratory, Eminent Biosciences, Vijaynagar, Indore Dept of Biotechnology, Softvision College, Vijayanagar, Indore Kalinga School of Biotechnology, Patia, Bhubaneswar, Odisha, Dept. of Bioinformatics, Dr. D. Y. Patil Biotechnology & Bioinformatics Institute,Tathawade, Pune, India.

 

ABSTRACT:

 

Anuraj Nayarisseri S, Sheaza Ahmed S, Mukesh Yadav D, Jyoti Sahu, Priyanka Gupta, Rachna Chourasia, Deepti Mittal R., In silico T-Cell Bacillus anthracis epitope protective antigen - lethal factors, Onl J Bioinform, 18(3):108-118, 2017. A major factor in the virulence of Bacillus anthracis is secretion of protective antigen, lethal and edema toxins. These toxins possess a common cell receptor-binding (B) component but have distinct biochemically active (A) components. We identified In silico T-Cell epitope and its binding affinity with MHC Class II with HLAPred. Ideal epitope peptide antigen, lipophilicity and solvency were determined. We identified 10 protective antigen and 5 lethal factors with best epitopic characteristics. Further studies to predict population coverage of T-cell epitope based on MHC binding data for epitope-based vaccines or diagnostics are required.

 

Keywords: T-Cell Epitope, Bacillus anthracis, Protective Antigen and Lethal factor.


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