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OJB©
Online Journal of Bioinformatics©
Onl J Bioinform©
Established 1995
ISSN 1443-2250
Volume 26 (1) :1-9, 2025.
In silico T cell antigens from proteome of H1N2 swine influenza A
virus
Sitansu Kumar Verma, Shivam Pratap
Singh Yadav, Ajay Kumar
Department of
Biotechnology, Institute of Biomedical Education and Research, Mangalayatan University,
Aligarh (U.P), India
ABSTRACT
Verma SK, Singh Yadav SP, Kumar A., In silico T cell
antigens from proteome of H1N2 swine influenza A virus, 26 (1) :1-9, 2025. Swine Influenza (H1N2) is a highly contagious
respiratory pathogen inducing swine flu in animals and humans. We screened
putative peptides for vaccine by epidemiological, clinical and laboratory
characteristics of patients with influenza A virus (H1N2). We applied Propred
and Propred I immune informatic
tools to predict T cell
epitopes from hemagglutinin , neuraminidase, polymerase, polymerasebasic 1, polymerase 2, matrix protein 1, matrix protein 2, nonstructural protein 1, nonstructural protein 2 and nucleocapsid protein of influenza virus (A/Sw/It/116114/2010) (H1N2). We found 21 epitopes for HLA class I and 20 for HLA class II molecules.
These T cell epitopes
yielded highest score peptides binding with most HLA alleles. Threshold was 4% high binding affinity peptides by Propred
I and Propred. The predicted T cell epitopes may be useful diagnostically
for evaluating T-cell responses in natural infection.
Keywords: T cell epitope, Propred, Influenza A virus (H1N2), Human Leukocyte antigen,
Computational vaccine.
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