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OJBTM

Online Journal of BioinformaticsTM

Volume 19 (2):181-188, 2018.


In silico prediction of antigenic epitope of coat protein from soybean dwarf virus.

 

Gomase VS1 and Chikhale NJ2.

 

1Govt. College of Pharmacy, Amravati (MS), 2Dept. of Biotechnology, Amravati University, Amravati (MS).

 

ABSTRACT

 

Gomase VS, Chikhale NJ., In silico prediction of antigenic epitope of coat protein from soybean dwarf virus, Onl J Bioinform., 19(2):181-188, 2018. Soybean dwarf virus susceptible host plant show systemic puckering, rugosity and yellowing of leaves, stunting (Glycine max), systemic leaf reddening (Trifolium incarnatum, T. subterraneum), systemic chlorosis and yellowing (Vicia faba), systemic leaf yellowing or reddening (Astragalus sinicus). Soybean dwarf virus (SbDV) infection of plant cells causes various diseases. SbDV infection of host cells produces structural and nonstructural proteins. One of these, the coat protein, is the major protein of the virion. This protein is believed to play an important role in a number of processes, including viral attachment, membrane fusion, and entry into the host cell. Antigenic epitopes on Coat protein [Soybean dwarf virus] are important determinants of protection against virus infection to the various plants. As our knowledge of the immune responses to a protein antigen progressed, it became clear that the whole protein is not necessary for raising the immune response, but small segments RAPRVQLMAVPTVTS; SDGILKAYHEYKITSILLQFIT, 20-34; 93-114 of coat protein called the antigenic determinants or the epitopes are sufficient for eliciting the desired immune response. In response to soybean dwarf virus infection, the host produces virus neutralizing antibodies and cytotoxic T cells (CTLs). The principal target for the neutralizing antibodies is the coat protein. It has been shown that protection against soybean dwarf virus infection is mainly antibody dependent, and virus-neutralizing antibodies alone are sufficient to impart. Peptide(s) from soybean dwarf virus protein that forms the virus-neutralizing epitope(s) could, therefore, be used for inducing soybean dwarf virus -neutralizing antibodies.

 

Keywords- Coat Protein, Antigenic epitope, immune response, secondary structure, hydrophobicity, hydrophilicity.


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