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OJBTM
Online Journal of Bioinformatics ©
Volume 15
(1): 87-97, 2014.
Structure prediction of alpha-synuclein protein and link with neurodegenerative disease.
Rashmika Singh1, 3, Navin K Gaur2, 3,
Ankur Mohan3, Pallavi
Gangwar3
1Institute of Engineering and
Technology, Lucknow, 2Harcourt Butler Technological Institute,
Kanpur, 3Bio-EGICORE (Dept. of Life Science of EGICORE) Lucknow,
India.
ABSTRACT
Singh
R, Gaur NK, Mohan A, Gangwar P., Structure prediction
of alpha-synuclein protein and link with
neurodegenerative disease, Onl J Bioinform.,
15(1)87-97, 2014. Neurodegenerative diseases, such as Parkinson’s disease (PD)
and Alzheimer’s disease (AD), are a group of pathologies characterized by a
progressive and specific loss of certain brain areas. The pathogenesis of these
disorders centrally involves abnormal accumulation and aggregation of specific
proteins. Pathological studies showed that Alpha-synuclein
protein is responsible for formation of intraneuronal
Lewy bodies and Lewy neuritis (hallmarks of PD) while others proteins like tau
and beta amyloid form extracellular β-amyloid deposits intracellular
neurofibrillary tangles (hallmarks of AD). However evidence from in vitro
and in vivo studies showed that these proteins are responsible for each
other’s aggregation with different seeding abilities. This idea is taken
further to develop a common therapeutic treatment for both the diseases by
targeting alpha synuclein pathologies involved in
both of them. Since the precise structure of alpha synuclein
protein is not yet available. Therefore, a theoretical model of this protein
was generated using homology Modeling. Validation of structure was done by
using PROCHECK available at SAVES server.
Keywords: Alzheimer’s
disease, Parkinson’s disease, SNCA, Homology Modeling, PMDB, SAVES.
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