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Online Journal of Bioinformatics©
Volume 6 (2):113-120, 2005.
DNA microarray model for computation of absolute gene expression level.
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Xu M., DNA microarray model for computation of absolute gene expression level, Onl J Bioinform., 6 (2) : 113-120, 2005. DNA microarray technology allows massive hybridization of thousands of genes to generate high through-put DNA hybridization data. The data is compared to obtain differential gene expression and is input into clustering program to find co-expressed or co-regulated genes. A drawback is that the DNA microarray hybridization data does not directly represent gene expression levels. Transcriptional gene expression profiling studies only define gene expression levels and changes, and there is a gap between microarray data and gene expression levels. A method to acquire the gene expression level of each individual gene using a higher dimensional DNA microarray data model which allows the gene expression profiling on the basis of gene expression levels instead of raw data, is described.
Key-Words: gene expression, expression levels, DNA model.