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OJB©
Online Journal of Bioinformatics©
Volume 6
(2):113-120, 2005.
DNA microarray model for
computation of absolute gene expression level.
Xu, M.
Gene21st, 19 Belcourt Rd. Worcester, MA 01605, USA.
ABSTRACT
Xu M., DNA
microarray model for computation of absolute gene expression level, Onl J Bioinform.,
6 (2) :
113-120, 2005. DNA microarray technology allows
massive hybridization of thousands of genes to generate high through-put DNA
hybridization data. The data is compared to obtain differential gene
expression and is input into clustering program to find co-expressed or
co-regulated genes. A drawback is that the DNA microarray hybridization data
does not directly represent gene expression levels. Transcriptional gene
expression profiling studies only define gene expression levels and changes,
and there is a gap between microarray data and gene expression levels. A method
to acquire the gene expression level of each individual gene using a higher
dimensional DNA microarray data model which allows the gene expression
profiling on the basis of gene expression levels instead of raw data, is
described.
Key-Words:
gene expression, expression levels, DNA model.